Engineering of skin on a microfluidic device for out-of-body investigation of the skin-related dynamics
In-vitro skin models are highly demanded for drug development and cosmetics testing. As the largest organ, skin serves as an important barrier against exogenous substances penetration and has various critical physiological functions that mostly regulated by capillaries within skin dermis.
Therefore, our long term goal is to develop in-vitro vascularized skin model by utilizing emerging multiscale fabrication methods. Due to its complexity, reconstruction of skin on new in-vitro model is very challenging and lot of problems should be tackled step by step. Recently, our team has developed micropore-embedded open top device that highly potential in co-culturing various skin in mimicking epidermis and dermis layer of skin.
Our team also has develop two-layered microfluidic platforms which can be used for testing chemical irritant. Besides, our group also investigate the integration of skin keratinocytes and endothelial cell within a standard microfluidic device. In the end, our works hopefully can be used as alternative platform especially for drug development and cosmetics testing.
Peer-Reviewed Conference Presentations
"MICROFLUIDIC APPROACH FOR TESTING CHEMICAL IRRITANTS MICROVESSELS NETWORK" Jihoon Ko, Soojung Oh Noo Li Jeon The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Ireland (Oct. 10, 2016)
"ENGINEERING OF IN VITRO 3D CAPILLARY BED IN MICRO-PORE-EMBEDDED MICROFLUIDICS" Soojung Oh, Hyun Ryul Ryu, Dongha Tahk, Jihoon Ko, Noo Li Jeon The 8th International Conference on Microtechnologies in Medicine and Biology (MMB 2016), Korea (Apr. 22, 2016)
"SKIN ANGIOGENESIS WITH KERATINOCYTES ON MICROFLUIDIC" Norhana Jusoh, Soojung Oh, Jin Young Lee, Hae Kwang Lee, Noo Li Jeon The 8th International Conference on Microtechnologies in Medicine and Biology ( MMB 2016), Korea (Apr. 21, 2016)
Multiscale Biomedical Engineering Laboratory, Department of Mechanical Engineering, Seoul National University, Rm. 401, Bldg. 312, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, KOREA (Republic of) COPYRIGHTSⓒ 2009 MBEL ALL RIGHTS RESERVED